Chih-Hsin Lin Selected Research

Melibiose

1/2020	Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.
1/2020	Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
1/2016	Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.
5/2015	The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment.

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Chih-Hsin Lin Research Topics

Disease

10	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/2020 - 01/2013
8	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2022 - 01/2013
6	Alzheimer Disease (Alzheimer's Disease) 07/2022 - 01/2016
5	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2014
4	Inflammation (Inflammations) 01/2021 - 10/2008
3	Neuroinflammatory Diseases 01/2021 - 01/2020
3	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2019 - 01/2013
3	Huntington Disease (Huntington's Disease) 01/2016 - 01/2013
2	Neuroblastoma 07/2022 - 01/2009
2	Tauopathies 01/2016 - 01/2016
1	Neuritis (Polyneuritis) 01/2020
1	Dementia (Dementias) 01/2019
1	Ataxia (Dyssynergia) 01/2019
1	Suppuration 01/2018
1	Frontotemporal Dementia (Semantic Dementia) 01/2018
1	Parkinsonian Disorders (Parkinsonism) 01/2018
1	Amyloid Plaque 02/2016
1	Mitochondrial Diseases (Mitochondrial Disease) 06/2014
1	Atrophy 06/2014
1	Neoplasms (Cancer) 10/2008
1	Neoplasm Metastasis (Metastasis) 10/2008

Drug/Important Bio-Agent (IBA)

9	polyglutamineIBA 11/2020 - 01/2013
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2013
4	Lactulose (Duphalac)FDA LinkGeneric 01/2020 - 05/2015
4	MelibioseIBA 01/2020 - 05/2015
3	Amyloid (Amyloid Fibrils)IBA 01/2021 - 02/2016
3	TrehalaseIBA 01/2020 - 05/2015
2	Phosphotransferases (Kinase)IBA 07/2022 - 06/2016
2	Pharmaceutical PreparationsIBA 01/2021 - 05/2015
2	SynucleinsIBA 01/2021 - 01/2020
2	glycyrrhizae radix et rhizomaIBA 01/2021 - 01/2019
2	tau Proteins (tau Protein)IBA 01/2021 - 01/2016
2	indoleIBA 01/2019 - 10/2014
2	tributyl phosphate (TBP)IBA 01/2019 - 01/2018
2	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2019 - 01/2018
2	TrehaloseIBA 01/2016 - 05/2015
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2022
1	Glycogen Synthase (Synthase I)IBA 07/2022
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	InterferonsIBA 01/2021
1	coumarinIBA 01/2021
1	Chalcone (Benzalacetophenone)IBA 01/2021
1	AntioxidantsIBA 11/2020
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2020
1	NC009-1 compoundIBA 01/2019
1	Apolipoproteins E (ApoE)IBA 01/2019
1	UbiquitinIBA 01/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	1,6-hexamethylene diisocyanate (hexamethylene diisocyanate)IBA 01/2018
1	CollagenIBA 01/2018
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2018
1	Polytetrafluoroethylene (Teflon)FDA Link 01/2018
1	Polyurethanes (Polyurethane)IBA 01/2018
1	polycaprolactoneIBA 01/2018
1	ProgranulinsIBA 01/2018
1	Complementary DNA (cDNA)IBA 01/2018
1	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 01/2018
1	EnzymesIBA 06/2016
1	Glycogen Synthase KinasesIBA 06/2016
1	DisaccharidesIBA 05/2015
1	Mutant Proteins (Protein, Mutant)IBA 06/2014
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2014
1	peoniflorinIBA 01/2013
1	lysophosphatidic acidIBA 08/2010
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 08/2010
1	LipidsIBA 08/2010
1	LuciferasesIBA 01/2009
1	Peptide Hydrolases (Proteases)FDA Link 10/2008
1	Vascular Endothelial Growth Factor CIBA 10/2008

Therapy/Procedure

3	Therapeutics 01/2021 - 10/2008
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2019 - 01/2016